The coenzyme your cells run on. Restored.
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme present in every living cell. It serves two critical functions: as an electron carrier in cellular energy production (the Krebs cycle and electron transport chain), and as a required substrate for sirtuins — enzymes central to DNA repair, gene expression regulation, and longevity signaling.
NAD+ levels decline approximately 50% between ages 40 and 60. This decline correlates with reduced mitochondrial efficiency, impaired DNA repair capacity, and declining function of NAD+-dependent enzymes. Restoring NAD+ levels has become a primary focus of longevity and metabolic health research.
NAD+ is required by sirtuins (SIRT1-7) — proteins that regulate gene expression, stress resistance, and cellular metabolism. As NAD+ rises, sirtuin activity increases, which drives a cascade of beneficial effects: improved mitochondrial biogenesis, enhanced DNA repair, reduced inflammation, and improved metabolic efficiency.
NAD+ is also consumed by PARP enzymes during DNA repair — when DNA damage is detected, PARPs use NAD+ to recruit repair machinery. Higher NAD+ means more capacity for ongoing DNA repair, which declines with age as both NAD+ and PARP activity fall.
Human studies with NAD+ precursors (NMN, NR) show improvements in energy metabolism, muscle function, and metabolic markers. Direct NAD+ administration produces faster restoration of cellular levels than oral precursors. Clinical research documents improvements in energy, cognitive clarity, and metabolic health markers.
The sublingual and oral drop delivery formats we use are designed to provide higher bioavailability than capsules — bypassing the digestive conversion steps that limit the efficiency of oral NAD+ precursors.
All information is for educational purposes. These statements have not been evaluated by the FDA. Products are not intended to diagnose, treat, cure, or prevent any disease.
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